Fc receptor-mediated inhibition of murine B-lymphocyte activation.
نویسندگان
چکیده
منابع مشابه
Fc receptor-mediated inhibition of murine B-lymphocyte activation
Immobilized antigen-antibody complexes are able to inhibit the mitogenic response of murine spleen cells to the B-cell mitogen 8-bromo-3',5'-cyclic guanosine monophosphoric acid. This this inhibition is dependent on intact Fc fragments in the immobilized complexes. Soluble complexes do not mediate this inhibition. When lipopolysaccharide (lps) activation of B cells was studied, it was found tha...
متن کاملB-cell-stimulatory factor 1 reverses Fc receptor-mediated inhibition of B-lymphocyte activation.
Intact (IgG class) rabbit anti-immunoglobulin antibodies are not mitogenic for mouse B cells but inhibit proliferation induced by F(ab')2 anti-Fab fragment antibodies (anti-Ig). In addition, cross-linkage of Fc and surface immunoglobulin receptors on B cells by intact anti-Ig inhibits inositol phospholipid breakdown (but not Ca2+ flux) resulting from ligation of antigen receptors. This system, ...
متن کاملInhibition of Fc g Receptor - Mediated Phagocytosis by a Nonphagocytic Fc g Receptor
There are three major classes of human Fcg receptors (FcgRI, FcgRII, and FcgRIII) and various isoforms of each class are capable of mediating phagocytosis. FcgRIIA is an unusual Fcg receptor in that it transmits a phagocytic signal in the absence of an additional receptor subunit. The cytoplasmic domain of FcgRIIA contains a conserved motif containing two copies of the sequence YXXL. The tyrosi...
متن کاملStatin inhibition of Fc receptor-mediated phagocytosis by macrophages is modulated by cell activation and cholesterol.
OBJECTIVES An inflammatory response to altered lipoproteins that accumulate in the arterial wall is a major component of the pathogenesis of atherosclerosis. Statins reduce plasma levels of low-density lipoprotein (LDL) and are effective treatments for atherosclerosis. It is hypothesized that they also modulate inflammation. The aim of this study was to examine whether lovastatin inhibits macro...
متن کاملIn vivo polyclonal B-lymphocyte activation elicited by murine viruses.
Viruses such as lactate dehydrogenase-elevating virus and adenovirus induce in vivo a polyclonal activation of murine B lymphocytes, followed by a marked increase in the production of immunoglobulin G2a (IgG2a). The role of T lymphocytes in this phenomenon was studied by injection of an anti-CD4 monoclonal antibody able to inhibit the T-helper function. This treatment profoundly depressed the p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1976
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.144.3.768